Positions Available
Postdoctoral
A postdoctoral fellow interested in the more biochemical side of glycobiology; experience with (or an interest in learning) MALDI-TOF mass spectrometry of glycans, structural analysis of oligosaccharides, and glycosyltransferase assays.
A postdoctoral fellow with an interest in mouse models in glycobiology; experience with (or an interest in learning) mouse biology.
Current projects are focused on understanding the role of glycosylation in Notch signaling, and determining the mechanism of fringe action. We showed in collaboration with others, that fringe is a b3N-acetylglucosaminyltransferase that acts directly on Notch to modulate Notch signaling. To investigate how fringe action alters Notch signaling, we are using a co-culture assay with CHO glycosylation mutants and ligand binding assays in vitro, and we are generating O-fucosyltransferase knockout mice. Other mouse models under study lack GlcNAc-TIII or GlcNAc-TI and have growth and developmental defects. New functions for complex and bisected N-glycans are being identified with these mice. CHO cells and CHO glycosylation mutants are being used to characterize "orphan" glycosyltransferases and to determine binding specificities and biological activities of galectins (provided by Hakon Leffler). CHO mutants with loss- or gain-of-function glycosylation mutations are being characterized at the molecular level for use in developing cell-based assays for glycan functions.
Albert Einstein offers the competitive Belfer and Harry Eagle postdoctoral fellowships that are prestigious and offer a good stipend. The fellowships are described on the lab home page which has links to our research, the department of Cell Biology, Einstein in general, the Einstein Postdoctoral Association, and most importantly, how it is to live in the residential neighborhood around Einstein (life@einstein).
Applicants should send a curriculum vitae with the names and contact information of three references to stanley@aecom.yu.edu
Graduate Students
Students who have completed a B. Sc. and who are interested in pursuing a Ph. D. degree in glycobiology should send a curriculum vitae and contact information of three references to stanley@aecom.yu.edu